Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Tfap2a  transcription factor AP-2, alpha   (Synonyms: Ap2, Ap-2 (a), AP2alpha, AP-2 alpha, Ap2tf, Tcfap2a)
Results	Reference
1	J:222437 Aoto K, Sandell LL, Butler Tjaden NE, Yuen KC, Watt KE, Black BL, Durnin M, Trainor PA, Mef2c-F10N enhancer driven beta-galactosidase (LacZ) and Cre recombinase mice facilitate analyses of gene function and lineage fate in neural crest cells. Dev Biol. 2015 Jun 1;402(1):3-16
1	J:288982 Assenza MR, Barbagallo F, Barrios F, Cornacchione M, Campolo F, Vivarelli E, Gianfrilli D, Auletta L, Soricelli A, Isidori AM, Lenzi A, Pellegrini M, Naro F, Critical role of phosphodiesterase 2A in mouse congenital heart defects. Cardiovasc Res. 2018 May 1;114(6):830-845
1	J:158712 Bassett EA, Williams T, Zacharias AL, Gage PJ, Fuhrmann S, West-Mays JA, AP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis. Hum Mol Genet. 2010 May 1;19(9):1791-804
1	J:152319 Calmont A, Ivins S, Van Bueren KL, Papangeli I, Kyriakopoulou V, Andrews WD, Martin JF, Moon AM, Illingworth EA, Basson MA, Scambler PJ, Tbx1 controls cardiac neural crest cell migration during arch artery development by regulating Gbx2 expression in the pharyngeal ectoderm. Development. 2009 Sep;136(18):3173-83
1	J:169235 Carbe C, Zhang X, Lens induction requires attenuation of ERK signaling by Nf1. Hum Mol Genet. 2011 Apr 1;20(7):1315-23
1	J:227058 Chen D, Wang X, Liang D, Gordon J, Mittal A, Manley N, Degenhardt K, Astrof S, Fibronectin signals through integrin alpha5beta1 to regulate cardiovascular development in a cell type-specific manner. Dev Biol. 2015 Nov 15;407(2):195-210
1	J:179212 Chen Y, Moon AM, Gaufo GO, Influence of mesodermal Fgf8 on the differentiation of neural crest-derived postganglionic neurons. Dev Biol. 2012 Jan 1;361(1):125-36
1*	J:91822 Chizhikov VV, Millen KJ, Control of roof plate formation by Lmx1a in the developing spinal cord. Development. 2004 Jun;131(11):2693-705
1	J:308916 De Zoysa P, Toubat O, Harvey D, Choi J, Kumar SR, Murine Model of Cardiac Defects Observed in Adams-Oliver Syndrome Driven by Delta-Like Ligand-4 Haploinsufficiency. Stem Cells Dev. 2021 Jun 15;30(12):611-621
1*	J:293794 Durbin MD, O'Kane J, Lorentz S, Firulli AB, Ware SM, SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects. Dev Biol. 2020 Aug 15;464(2):124-136
1*	J:207523 Edlund RK, Ohyama T, Kantarci H, Riley BB, Groves AK, Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers. Dev Biol. 2014 Jun 1;390(1):1-13
1	J:159118 Fotopoulou S, Oikonomou N, Grigorieva E, Nikitopoulou I, Paparountas T, Thanassopoulou A, Zhao Z, Xu Y, Kontoyiannis DL, Remboutsika E, Aidinis V, ATX expression and LPA signalling are vital for the development of the nervous system. Dev Biol. 2010 Mar 15;339(2):451-64
1	J:78685 Frank DU, Fotheringham LK, Brewer JA, Muglia LJ, Tristani-Firouzi M, Capecchi MR, Moon AM, An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome. Development. 2002 Oct;129(19):4591-603
1	J:178934 Freyer L, Aggarwal V, Morrow BE, Dual embryonic origin of the mammalian otic vesicle forming the inner ear. Development. 2011 Dec;138(24):5403-14
1	J:212854 Gregoire S, Karra R, Passer D, Deutsch MA, Krane M, Feistritzer R, Sturzu A, Domian I, Saga Y, Wu SM, Essential and unexpected role of Yin Yang 1 to promote mesodermal cardiac differentiation. Circ Res. 2013 Mar 15;112(6):900-10
1	J:146472 Grenier J, Teillet MA, Grifone R, Kelly RG, Duprez D, Relationship between neural crest cells and cranial mesoderm during head muscle development. PLoS One. 2009;4(2):e4381
1	J:191738 Harel I, Maezawa Y, Avraham R, Rinon A, Ma HY, Cross JW, Leviatan N, Hegesh J, Roy A, Jacob-Hirsch J, Rechavi G, Carvajal J, Tole S, Kioussi C, Quaggin S, Tzahor E, Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18839-44
1	J:152574 High FA, Jain R, Stoller JZ, Antonucci NB, Lu MM, Loomes KM, Kaestner KH, Pear WS, Epstein JA, Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. J Clin Invest. 2009 Jul;119(7):1986-96
1	J:163030 Horn Z, Ringstedt T, Blaesse P, Kaila K, Herlenius E, Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism. Eur J Neurosci. 2010 Jun;31(12):2142-55
1*	J:70060 Ikeda A, Ikeda S, Gridley T, Nishina PM, Naggert JK, Neural tube defects and neuroepithelial cell death in Tulp3 knockout mice. Hum Mol Genet. 2001 Jun 1;10(12):1325-34
1	J:109474 Ilagan R, Abu-Issa R, Brown D, Yang YP, Jiao K, Schwartz RJ, Klingensmith J, Meyers EN, Fgf8 is required for anterior heart field development. Development. 2006 Jun;133(12):2435-45
1*	J:297161 Javali A, Lakshmanan V, Palakodeti D, Sambasivan R, Modulation of beta-catenin levels regulates cranial neural crest patterning and dispersal into first pharyngeal arch. Dev Dyn. 2020 May 19;
1	J:320915 Johnson AL, Schneider JE, Mohun TJ, Williams T, Bhattacharya S, Henderson DJ, Phillips HM, Bamforth SD, Early Embryonic Expression of AP-2alpha Is Critical for Cardiovascular Development. J Cardiovasc Dev Dis. 2020 Jul 23;7(3):27
1	J:330214 Lania G, Franzese M, Adachi N, Bilio M, Flore G, Russo A, D'Agostino E, Angelini C, Kelly RG, Baldini A, A phenotypic rescue approach identifies lineage regionalization defects in a mouse model of DiGeorge syndrome. Dis Model Mech. 2022 Sep 1;15(9):dmm049415
1	J:206320 Lee RT, Nagai H, Nakaya Y, Sheng G, Trainor PA, Weston JA, Thiery JP, Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme. Development. 2013 Dec;140(24):4890-902
1	J:316198 Lei R, Zhang K, Liu K, Shao X, Ding Z, Wang F, Hong Y, Zhu M, Li H, Li H, Transferrin receptor facilitates TGF-beta and BMP signaling activation to control craniofacial morphogenesis. Cell Death Dis. 2016 Jun 30;7(6):e2282
1	J:293699 Lin JI, Feinstein TN, Jha A, McCleary JT, Xu J, Arrigo AB, Rong G, Maclay LM, Ridge T, Xu X, Lo CW, Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening. Commun Biol. 2020 Jun 16;3(1):312
1*	J:277316 Lukacs M, Roberts T, Chatuverdi P, Stottmann RW, Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival. Elife. 2019 Jun 24;8:e45248
1	J:229604 Machon O, Masek J, Machonova O, Krauss S, Kozmik Z, Meis2 is essential for cranial and cardiac neural crest development. BMC Dev Biol. 2015;15:40
1	J:160496 Makki N, Capecchi MR, Hoxa1 lineage tracing indicates a direct role for Hoxa1 in the development of the inner ear, the heart, and the third rhombomere. Dev Biol. 2010 May 15;341(2):499-509
1	J:155154 Mesbah K, Harrelson Z, Theveniau-Ruissy M, Papaioannou VE, Kelly RG, Tbx3 is required for outflow tract development. Circ Res. 2008 Sep 26;103(7):743-50
1	J:181153 Mesbah K, Rana MS, Francou A, van Duijvenboden K, Papaioannou VE, Moorman AF, Kelly RG, Christoffels VM, Identification of a Tbx1/Tbx2/Tbx3 genetic pathway governing pharyngeal and arterial pole morphogenesis. Hum Mol Genet. 2012 Mar 15;21(6):1217-29
1	J:214961 Milgrom-Hoffman M, Michailovici I, Ferrara N, Zelzer E, Tzahor E, Endothelial cells regulate neural crest and second heart field morphogenesis. Biol Open. 2014;3(8):679-88
1*	J:165711 Mittal A, Pulina M, Hou SY, Astrof S, Fibronectin and integrin alpha 5 play essential roles in the development of the cardiac neural crest. Mech Dev. 2010 Sep-Dec;127(9-12):472-84
1	J:189708 Murdoch B, DelConte C, Garcia-Castro MI, Pax7 lineage contributions to the mammalian neural crest. PLoS One. 2012;7(7):e41089
1	J:263684 Nie X, Zheng J, Ricupero CL, He L, Jiao K, Mao JJ, mTOR acts as a pivotal signaling hub for neural crest cells during craniofacial development. PLoS Genet. 2018 Jul;14(7):e1007491
1	J:334337 Odelin G, Faucherre A, Marchese D, Pinard A, Jaouadi H, Le Scouarnec S, Chiarelli R, Achouri Y, Faure E, Herbane M, Theron A, Avierinos JF, Jopling C, Collod-Beroud G, Rezsohazy R, Zaffran S, Variations in the poly-histidine repeat motif of HOXA1 contribute to bicuspid aortic valve in mouse and zebrafish. Nat Commun. 2023 Mar 20;14(1):1543
1*	J:306393 Ofek S, Wiszniak S, Kagan S, Tondl M, Schwarz Q, Kalcheim C, Notch signaling is a critical initiator of roof plate formation as revealed by the use of RNA profiling of the dorsal neural tube. BMC Biol. 2021 Apr 23;19(1):84
1	J:267985 Page M, Ridge L, Gold Diaz D, Tsogbayar T, Scambler PJ, Ivins S, Loss of CXCL12/CXCR4 signalling impacts several aspects of cardiovascular development but does not exacerbate Tbx1 haploinsufficiency. PLoS One. 2018;13(11):e0207251
1	J:297650 Roeseler DA, Strader L, ANderson MJ, Waters ST, Gbx2 is required for the migration and survival of a subpopulation of trigeminal cranial neural crest cells. J Dev Biol. 2020;8(33)
1*	J:226322 Roux M, Laforest B, Capecchi M, Bertrand N, Zaffran S, Hoxb1 regulates proliferation and differentiation of second heart field progenitors in pharyngeal mesoderm and genetically interacts with Hoxa1 during cardiac outflow tract development. Dev Biol. 2015 Oct 15;406(2):247-58
1	J:170865 Ryckebusch L, Bertrand N, Mesbah K, Bajolle F, Niederreither K, Kelly RG, Zaffran S, Decreased levels of embryonic retinoic acid synthesis accelerate recovery from arterial growth delay in a mouse model of DiGeorge syndrome. Circ Res. 2010 Mar 5;106(4):686-94
1	J:173638 Schmidt M, Huber L, Majdazari A, Schutz G, Williams T, Rohrer H, The transcription factors AP-2beta and AP-2alpha are required for survival of sympathetic progenitors and differentiated sympathetic neurons. Dev Biol. 2011 Jul 1;355(1):89-100
1	J:281204 Sen R, Pezoa SA, Carpio Shull L, Hernandez-Lagunas L, Niswander LA, Artinger KB, Kat2a and Kat2b Acetyltransferase Activity Regulates Craniofacial Cartilage and Bone Differentiation in Zebrafish and Mice. J Dev Biol. 2018 Nov 12;6(4)
1	J:119303 Seo S, Kume T, Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract. Dev Biol. 2006 Aug 15;296(2):421-36
1	J:101264 Smith AN, Miller LA, Song N, Taketo MM, Lang RA, The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. Dev Biol. 2005 Sep 15;285(2):477-89
1	J:279272 Wang JJ, Liu HX, Song L, Li HR, Yang YP, Zhang T, Jing Y, Isl-1 positive pharyngeal mesenchyme subpopulation and its role in the separation and remodeling of the aortic sac in embryonic mouse heart. Dev Dyn. 2019 Sep;248(9):771-783
1	J:178707 Wang SK, Komatsu Y, Mishina Y, Potential contribution of neural crest cells to dental enamel formation. Biochem Biophys Res Commun. 2011 Nov 11;415(1):114-9
1	J:170879 Watanabe Y, Miyagawa-Tomita S, Vincent SD, Kelly RG, Moon AM, Buckingham ME, Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries. Circ Res. 2010 Feb 19;106(3):495-503
1	J:52402 West-Mays JA, Zhang J, Nottoli T, Hagopian-Donaldson S, Libby D, Strissel KJ, Williams T, AP-2alpha transcription factor is required for early morphogenesis of the lens vesicle. Dev Biol. 1999 Feb 1;206(1):46-62
1	J:243987 Zalc A, Rattenbach R, Aurade F, Cadot B, Relaix F, Pax3 and Pax7 play essential safeguard functions against environmental stress-induced birth defects. Dev Cell. 2015 Apr 06;33(1):56-66
1	J:336422 Zbasnik N, Fish JL, Fgf8 regulates first pharyngeal arch segmentation through pouch-cleft interactions. Front Cell Dev Biol. 2023;11:1186526
1	J:143443 Zhang J, Lin Y, Zhang Y, Lan Y, Lin C, Moon AM, Schwartz RJ, Martin JF, Wang F, Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis. Development. 2008 Nov;135(21):3611-22